Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes
Inoue T, Abe C, Sung SSJ, Moscalu S, Jankowski J, Huang L, Ye H, Rosin DL, Guyenet PG, Okusa MD
Journal of Clinical Investigation · 2016
Key finding
Together, these results demonstrate that VNS-mediated attenuation of AKI and systemic inflammation depends on α7nAChR-positive splenocytes.
Auto-extracted · verification pendingHow we verify
- Condition
- Kidney Disease
- Stimulation
- iVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- —
Share this study
Download the citation card as a PNG, or copy a link to this page.
Cite this study
Inoue, T., Abe, C., Sung, S. S. J., Moscalu, S., Jankowski, J., Huang, L., Ye, H., Rosin, D. L., Guyenet, P. G., & Okusa, M. D. (2016). Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes. Journal of Clinical Investigation, 126(5), 1939-1952. https://doi.org/10.1172/JCI83658
Related studies in Kidney Disease
Transcutaneous auricular vagus nerve stimulation improves cognitive decline by alleviating intradialytic cerebral hypoxia in hemodialysis patients: A fNIRS pilot study
Wang et al. · Heliyon · 2024 · Controlled Clinical Trial
Neuroimmune Control of Inflammation in Acute Kidney Injury and Multiorgan Dysfunction
Goggins et al. · Journal of the American Society of Nephrology : JASN · 2025 · Narrative / Scoping Review
The role of neuromodulation in heart failure with preserved ejection fraction
Algheffari et al. · Current problems in cardiology · 2025 · Narrative / Scoping Review
Vagal modulation of hypertension
Petkovich et al. · Current hypertension reports · 2015 · Narrative / Scoping Review
Summary by Vagus Research. Always consult the primary source for the authoritative record.