Effect of reversible intermittent intra-abdominal vagal nerve blockade on morbid obesity: the ReCharge randomized clinical trial
Ikramuddin S, Blackstone RP, Brancatisano A, Toouli J, Shah SN, Wolfe BM, Fujioka K, Maher JW, Swain J, Que FG, et al.
JAMA · 2014
Key finding
In 239 patients, vagal nerve block produced 24.4% excess weight loss versus 15.9% with sham at 12 months, meeting the trial's a-priori safety threshold but not its efficacy margin over sham.
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- Condition
- Obesity
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 239
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Cite this study
Ikramuddin, S., Blackstone, R. P., Brancatisano, A., Toouli, J., Shah, S. N., Wolfe, B. M., Fujioka, K., Maher, J. W., Swain, J., Que, F. G., Morton, J. M., Leslie, D. B., Brancatisano, R., Kow, L., O’Rourke, R. W., Deveney, C., Takata, M., Miller, C. J., Knudson, M. B., … Billington, C. J. (2014). Effect of reversible intermittent intra-abdominal vagal nerve blockade on morbid obesity: the ReCharge randomized clinical trial. JAMA, 312(9), 915. https://doi.org/10.1001/jama.2014.10540
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