Closed-Loop Vagus Nerve Stimulation Delivered With a Miniaturized System Produces Lasting Recovery in Individuals With Chronic Stroke
Hays SA, Adehunoluwa EA, Epperson JD, Malley KM, Porter AL, Gallaway HL, Swank C, Carrera ÁJ, Stevens C, Gillespie J, et al.
Stroke · 2026
Key finding
A randomised sham-controlled trial of a miniaturised closed-loop VNS system found it safe and feasible, producing lasting upper-limb recovery in chronic stroke.
- Condition
- Stroke Rehabilitation
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 19
Cite this study
Hays, S. A., Adehunoluwa, E. A., Epperson, J. D., Malley, K. M., Porter, A. L., Gallaway, H. L., Swank, C., Carrera, Á. J., Stevens, C., Gillespie, J., Arnold, D., Kian, S., Bynum, Z. S., Meyers, E. C., Bleker, N., Naftalis, R. C., Foreman, M. L., Hamilton, R. G., Rennaker, R. L., … Wigginton, J. G. (2026). Closed-Loop Vagus Nerve Stimulation Delivered With a Miniaturized System Produces Lasting Recovery in Individuals With Chronic Stroke. Stroke, 57(1), 38-49. https://doi.org/10.1161/strokeaha.125.052937
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