Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial
Handforth A, DeGiorgio CM, Schachter SC, Uthman BM, Naritoku DK, Tecoma ES, Henry TR, Collins SD, Vaughn BV, Gilmartin RC, et al.
Neurology · 1998
Key finding
High-stimulation VNS produced a significantly greater reduction in seizure frequency (28%) compared to low-stimulation controls (15%) in drug-resistant epilepsy.
- Condition
- Epilepsy
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 254
Cite this study
Handforth, A., DeGiorgio, C. M., Schachter, S. C., Uthman, B. M., Naritoku, D. K., Tecoma, E. S., Henry, T. R., Collins, S. D., Vaughn, B. V., Gilmartin, R. C., Labar, D. R., Morris, G. L., Salinsky, M. C., Osorio, I., Ristanovic, R. K., Labiner, D. M., Jones, J. C., Murphy, J. V., Ney, G. C., & Wheless, J. W. (1998). Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurology, 51(1), 48-55. https://doi.org/10.1212/WNL.51.1.48
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Summary by Vagus Research. Always consult the primary source for the authoritative record.