Modulation of brainstem activity and connectivity by respiratory-gated auricular vagal afferent nerve stimulation in migraine patients
Garcia R, Lin R, Lee J, Kim J, Barbieri R, Sclocco R, Wasan A, Edwards R, Rosen B, Hadjikhani N, et al.
Pain · 2017
Key finding
Respiratory-gated auricular VNS in migraine patients modulated fMRI activity and connectivity of the spinal trigeminal nucleus and pontine brainstem, with exhalation-gating producing the strongest effects.
- Condition
- Neuroimaging
- Stimulation
- taVNS
- Evidence tier
- Observational / Cohort
- Participants
- 32
Cite this study
Garcia, R., Lin, R., Lee, J., Kim, J., Barbieri, R., Sclocco, R., Wasan, A., Edwards, R., Rosen, B., Hadjikhani, N., & Napadow, V. (2017). Modulation of brainstem activity and connectivity by respiratory-gated auricular vagal afferent nerve stimulation in migraine patients. Pain.
Related studies in Neuroimaging
Cognitive function and brain activation before and after transcutaneous cervical vagus nerve stimulation in healthy adults: A concurrent tcVNS-fMRI study
Zhang et al. · Frontiers in psychology · 2022 · Randomised Controlled Trial
Optimization of transcutaneous vagus nerve stimulation using functional MRI
Yakunina et al. · Neuromodulation · 2017 · Randomised Controlled Trial
Non-invasive access to the vagus nerve central projections via electrical stimulation of the external ear: fMRI evidence in humans
Frangos et al. · Brain Stimulation · 2015 · Randomised Controlled Trial
The impact of transcutaneous vagus nerve stimulation on anterior cingulate cortex activity in a cognitive control task
Sönmez et al. · Psychophysiology · 2025 · Controlled Clinical Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.