ATP release and metabolism by human and guinea pig airways and P2X receptor-dependent effects on bronchopulmonary vagal afferent nerve subtypes
Canning BJ, Yoshihara M, Mori N, Tsujimura T, Inoue M, Meeker S, Liu Q, Undem BJ
British Journal of Pharmacology · 2026
Key finding
It is also unclear whether P2X receptor blockade could compromise the essential defensive functions of cough regulated by the vagal Aδ-fibres terminating in the extrapulmonary airways.
Auto-extracted · verification pendingHow we verify
- Condition
- Respiratory
- Stimulation
- tcVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- —
Share this study
Download the citation card as a PNG, or copy a link to this page.
Cite this study
Canning, B. J., Yoshihara, M., Mori, N., Tsujimura, T., Inoue, M., Meeker, S., Liu, Q., & Undem, B. J. (2026). ATP release and metabolism by human and guinea pig airways and P2X receptor-dependent effects on bronchopulmonary vagal afferent nerve subtypes. British Journal of Pharmacology, 183(5), 1071-1084. https://doi.org/10.1111/bph.70238
Related studies in Respiratory
Vagus nerve stimulation as a potential treatment for acute asthmatic bronchoconstriction: a systematic review
Di Flumeri et al. · Frontiers in physiology · 2025 · Systematic Review / Meta-Analysis
Vagal nerve stimulator-associated sleep disordered breathing secondary to vagal-induced laryngospasm in pediatric populations: Case presentation and systematic review
Sharma et al. · International journal of pediatric otorhinolaryngology · 2023 · Systematic Review / Meta-Analysis
Prevalence of Arnold Nerve Reflex in Adults and Children With Chronic Cough
Dicpinigaitis et al. · Chest · 2018 · Controlled Clinical Trial
Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways
Tränkner et al. · Proceedings of the National Academy of Sciences of the United States of America · 2014 · Controlled Clinical Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.