ATP release and metabolism by human and guinea pig airways and P2X receptor-dependent effects on bronchopulmonary vagal afferent nerve subtypes
Canning BJ, Yoshihara M, Mori N, Tsujimura T, Inoue M, Meeker S, Liu Q, Undem BJ
British Journal of Pharmacology · 2026
Key finding
It is also unclear whether P2X receptor blockade could compromise the essential defensive functions of cough regulated by the vagal Aδ-fibres terminating in the extrapulmonary airways.
- Condition
- Respiratory
- Stimulation
- tcVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- —
Cite this study
Canning, B. J., Yoshihara, M., Mori, N., Tsujimura, T., Inoue, M., Meeker, S., Liu, Q., & Undem, B. J. (2026). ATP release and metabolism by human and guinea pig airways and P2X receptor-dependent effects on bronchopulmonary vagal afferent nerve subtypes. British Journal of Pharmacology, 183(5), 1071-1084. https://doi.org/10.1111/bph.70238
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Summary by Vagus Research. Always consult the primary source for the authoritative record.