Transcutaneous vagal nerve stimulation blocks stress-induced activation of Interleukin-6 and interferon-gamma in posttraumatic stress disorder: A double-blind, randomized, sham-controlled trial
Bremner JD, Gurel NZ, Jiao Y, Wittbrodt MT, Levantsevych OM, Huang M, Jung H, Shandhi MH, Beckwith J, Herring I, et al.
Brain, Behavior, & Immunity - Health · 2020
Key finding
tcVNS blocked stress-induced increases in IL-6 and IFN-gamma in PTSD patients, demonstrating anti-inflammatory effects of vagal stimulation during traumatic stress exposure.
- Condition
- PTSDInflammation
- Stimulation
- tcVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 25
Cite this study
Bremner, J. D., Gurel, N. Z., Jiao, Y., Wittbrodt, M. T., Levantsevych, O. M., Huang, M., Jung, H., Shandhi, M. H., Beckwith, J., Herring, I., Rapaport, M. H., Murrah, N., Driggers, E., Ko, Y. A., Alkhalaf, M. L., Soudan, M., Song, J., Ku, B. S., Shallenberger, L., … Pearce, B. D. (2020). Transcutaneous vagal nerve stimulation blocks stress-induced activation of Interleukin-6 and interferon-gamma in posttraumatic stress disorder: A double-blind, randomized, sham-controlled trial. Brain, Behavior, & Immunity - Health, 9, 100138. https://doi.org/10.1016/j.bbih.2020.100138
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Summary by Vagus Research. Always consult the primary source for the authoritative record.