Transcutaneous vagal nerve stimulation blocks stress-induced activation of Interleukin-6 and interferon-gamma in posttraumatic stress disorder: A double-blind, randomized, sham-controlled trial
Bremner JD, Gurel NZ, Jiao Y, Wittbrodt MT, Levantsevych OM, Huang M, Jung H, Shandhi MH, Beckwith J, Herring I, et al.
Brain, Behavior, & Immunity - Health · 2020
Key finding
In trauma-exposed individuals, tcVNS blunted stress-induced rises in the inflammatory markers IL-6 and IFN-γ versus sham (results not in the indexed abstract; low confidence).
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- Condition
- PTSDInflammation
- Stimulation
- tcVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 25
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Cite this study
Bremner, J. D., Gurel, N. Z., Jiao, Y., Wittbrodt, M. T., Levantsevych, O. M., Huang, M., Jung, H., Shandhi, M. H., Beckwith, J., Herring, I., Rapaport, M. H., Murrah, N., Driggers, E., Ko, Y. A., Alkhalaf, M. L., Soudan, M., Song, J., Ku, B. S., Shallenberger, L., … Pearce, B. D. (2020). Transcutaneous vagal nerve stimulation blocks stress-induced activation of Interleukin-6 and interferon-gamma in posttraumatic stress disorder: A double-blind, randomized, sham-controlled trial. Brain, Behavior, & Immunity - Health, 9, 100138. https://doi.org/10.1016/j.bbih.2020.100138
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