Condition · Evidence Hub
Vagus Nerve Stimulation for Sepsis
Does vagus nerve stimulation help with sepsis? 1 human study has investigated VNS for sepsis, including 1 narrative review, published in 2012. The study uses implanted (iVNS) stimulation. Findings vary by study design and population; the study below is ranked by evidence strength so you can weigh the research directly.
1 narrative review
Evidence by Tier
strongest → weakest
- 1Narrative & scoping reviews
Stimulation Method
- 1iVNS
Research Momentum
0 of 1 study (0%) published since 2022.
The studies
1 study · strongest evidence firstThe vagus nerve and the inflammatory reflex: wandering on a new treatment paradigm for systemic inflammation and sepsis
Huston · Surgical infections · 2012
narrative reviewsiVNS
Registered trials — results pending
2 registered protocols with no published results yet. Listed for context; not counted in the evidence total.
Effects of transcutaneous auricular vagus nerve stimulation on sepsis-induced coagulopathy: protocol for a randomised controlled trial
Yang et al. · 2025 · protocol
Non-invasive Auricular Vagus nerve stimulation for Subarachnoid Hemorrhage (NAVSaH): Protocol for a prospective, triple-blinded, randomized controlled trial
Huguenard et al. · 2024 · protocol